Quercetin is a plant-based bioflavonoid found in onions, apples, berries, and green tea. This powerful antioxidant is known for its anti-inflammatory and immunomodulatory effects, but in recent years, it has gained particular attention for its ability to regulate histamine. This makes quercetin an intriguing compound for people with allergies, mast cell activation syndrome (MCAS), and histamine intolerance.
💉 What Does Quercetin Do with Histamine?
Quercetin influences histamine balance through multiple mechanisms:
- Stabilizes mast cells: Mast cells are the main source of histamine in the body. Quercetin prevents these cells from releasing histamine too quickly or excessively in response to triggers such as stress, allergens, or estrogen.
- Inhibits histamine synthesis: Quercetin reduces the activity of histidine decarboxylase, the enzyme that converts histidine into histamine.
- Improves barrier function: It strengthens the mucous membranes in the gut, nose, and lungs, reducing histamine absorption from the environment.
- Acts as an antioxidant and anti-inflammatory: By neutralizing free radicals and inhibiting inflammatory pathways (such as NF-κB), quercetin indirectly lowers histamine sensitivity.
🌿 Natural Sources and Absorption
Quercetin is naturally found in plants, especially in:
- Red onion
- Apple (with skin)
- Dark berries
- Capers
- Green tea
For therapeutic effects, supplements are often needed. Since quercetin is poorly absorbed, improved forms are commonly used, such as quercetin dihydrate or combinations with bromelain or vitamin C.
⚠️ Application in Histamine Intolerance
Quercetin is a key ingredient in many supplements targeting histamine intolerance or MCAS:
- Reduces symptoms such as hives, sneezing, itching, asthma, and abdominal cramps
- Can be used as an alternative or complement to antihistamines
- Supports people with genetic weaknesses in DAO, HNMT, or MAO
✅ Dosage and Safety
Typical dosage ranges between 250 - 1000 mg per day, divided over 2 or 3 doses. It is generally safe, but high doses may cause stomach discomfort. Use under guidance during pregnancy, breastfeeding, or when combined with medications (such as antibiotics or blood thinners).
📅 Conclusion
Quercetin is a versatile natural compound with an impressive profile as a mast cell stabilizer and antihistamine. It gently supports the body in regulating histamine, especially for those dealing with sensitivities, allergies, or hormonal imbalances.
When histamine disrupts the system, quercetin offers calm, balance, and protection.